Alcohol: severe hypotension and cardiovascular collapse may occur.
Aspirin: increase nitrate serum concentrations and actions may occur.
Calcium channel blockers: may decrease symptomatic orthostatic hypotension. Dosage adjustment of either agent may be necessary and maked decreasing the antianginal effects.
Dihydroergotamine: increase bioavailability of dihydroergotamine.
Nitroglycerin: pharmacologic effects of heparin may be decreased.